{"id":5851,"date":"2024-04-03T17:50:01","date_gmt":"2024-04-03T17:50:01","guid":{"rendered":"https:\/\/www.nonsolomusicamagazine.it\/?p=5851"},"modified":"2024-04-03T17:50:02","modified_gmt":"2024-04-03T17:50:02","slug":"fegato-umano-su-chip-per-la-tossicologia-predittiva-funziona-meglio-degli-animali-isde-news","status":"publish","type":"post","link":"https:\/\/www.nonsolomusicamagazine.it\/?p=5851","title":{"rendered":"Fegato umano su chip per la tossicologia predittiva: funziona meglio degli animali (Isde News)"},"content":{"rendered":"\n<p>&nbsp;modelli preclinici convenzionali (<strong>modelli animali e moelli in vitro inadeguati<\/strong>) spesso non sono in grado di rilevare la tossicit\u00e0 dei farmaci, che si manifesta soltanto quando questi arrivano alle successive fasi cliniche o sul mercato,&nbsp;<strong>mettendo a rischio la salute e la vita delle persone<\/strong>.<\/p>\n\n\n\n<p>La tecnologia degli organi su chip (Organs-on-Chip) ha il potenziale per migliorare il successo nella produzione e sviluppo di farmaci, in quanto tali sistemi sono in grado di modellare adeguatamente la fisiopatologia umana e le risposte cliniche; tuttavia, non sono state ancora riportate valutazioni sistematiche e quantitative del valore predittivo di tali sistemi.<\/p>\n\n\n\n<p>Attraverso questo studio gli autori hanno valutato le performance di modelli di fegato umano su chip (Liver-Chips) nell\u2019ambito della tossicologia. Gli autori hanno analizzato 870 unit\u00e0 di fegato umano su chip per determinare la loro capacit\u00e0 di prevedere il danno epatico indotto da farmaci, una causa comune di fallimento del farmaci, scoprendo che i Liver-Chips superavano i modelli convenzionali.<\/p>\n\n\n\n<p>Questi risultati suggeriscono che l\u2019adozione su larga scala degli Organs-on-Chip potrebbe ridurre il tasso di fallimento del processo di produzione e sviluppo di nuovi farmaci,\u00a0<strong>aiutare a ridurre al minimo il rischio di danni ai pazienti<\/strong>\u00a0e generare ingenti entrate economiche per l\u2019industria farmaceutica.<\/p>\n\n\n<figure class=\"wp-block-post-featured-image\"><img decoding=\"async\" width=\"678\" height=\"381\" src=\"https:\/\/www.nonsolomusicamagazine.it\/wp-content\/uploads\/2024\/04\/liver-chip2.png\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"\" style=\"object-fit:cover;\" srcset=\"https:\/\/www.nonsolomusicamagazine.it\/wp-content\/uploads\/2024\/04\/liver-chip2.png 678w, https:\/\/www.nonsolomusicamagazine.it\/wp-content\/uploads\/2024\/04\/liver-chip2-300x169.png 300w\" sizes=\"(max-width: 678px) 100vw, 678px\" \/><\/figure>","protected":false},"excerpt":{"rendered":"<p>&nbsp;modelli preclinici convenzionali (modelli animali e moelli in vitro inadeguati) spesso non sono in grado di rilevare la tossicit\u00e0 dei farmaci, che si manifesta soltanto quando questi arrivano alle successive fasi cliniche o sul mercato,&nbsp;mettendo a rischio la salute e la vita delle persone. La tecnologia degli organi su chip (Organs-on-Chip) ha il potenziale per [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5853,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[107,1005],"tags":[3087,1171,2224],"class_list":["post-5851","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salute","category-scienza","tag-esperimenti","tag-isde","tag-tumori"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fegato umano su chip per la tossicologia predittiva: funziona meglio degli animali (Isde News) - NonSoloMusicaMagazine<\/title>\n<meta name=\"description\" content=\"Fegato umano su chip per la tossicologia predittiva: funziona meglio degli animali (Isde News)\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.nonsolomusicamagazine.it\/?p=5851\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fegato umano su chip per la tossicologia predittiva: funziona meglio degli animali (Isde News) - 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